REACTIVE BLUE 2
REACTIVE BLUE 2
CAS: 12236-82-7
Molecular Formula: C29H20ClN7O11S3
REACTIVE BLUE 2 - Names and Identifiers
REACTIVE BLUE 2 - Physico-chemical Properties
| Molecular Formula | C29H20ClN7O11S3 |
| Molar Mass | 774.16 |
| Solubility | H2O: soluble |
| Appearance | saline suspension |
| Color | dark blue |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| In vitro study | Reactive Blue 2 is used as an ATP receptor antagonist and induces Ca 2+ oscillations in HeLa cells. Reactive Blue 2 enhances a Ca 2+ response to histamine that is linked to the PLC cascade. Reactive Blue 2 may activate the PLC cascade in an extracellular Ca 2+ -dependent manner and induce Ca 2+ oscillations. The application of Reactive Blue 2 increases K + secretion in a dose-dependent manner, and this increase is characterized as a peak followed by a partial relaxation to a steady-state. Reactive Blue 2 has antagonistic activities at P2Y4, and the antagonist potency at P2Y4 paralleled the potency of K+ secretion.The anthraquinone dye reactive blue 2 is found to be a potent inhibitor of a protein kinase isolated and purified from thylakoids. The mode of inhibition is noncompetitive, with a K i of 8 μM for the membrane-bound kinase, and 6 microM for the purified kinase. The inhibitor does not modify the substrate preference of the endogenous kinase and could be removed from the membrane by washing. Reactive blue 2 selectively inhibits responses mediated via the P2ypurinoceptor, at least within a limited concentration range. In preparations where the tone has been raised with noradrenaline, ATP and 2-methylthio ATP, but not α,β-methylene ATP, produce relaxations of the vessel. These relaxations are inhibited in the presence of reactive blue 2. Reactive blue 2, at concentrations of 0.3-10 μM blocks the ATP-induced oscillation in a concentration-dependent manner. |
REACTIVE BLUE 2 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-21 |
REACTIVE BLUE 2 - Reference
| Reference Show more | 1. [IF=0] Dong-Hao Zhang et al."Effects of different spacer arms on Cibacron Blue modification and protein affinity adsorption on magnetic microspheres."J Mol Catal B Enzym. 2016 Nov;133:136 2. [IF=5.328] Li Xin Ping et al."The signaling role of extracellular ATP in co-culture of Shiraia sp. S9 and Pseudomonas fulva SB1 for enhancing hypocrellin A production."Microb Cell Fact. 2021 Dec;20(1):1-15 3. [IF=3.174] Yu-Pei Xia et al."An efficient protein immobilization strategy: protein encapsulated in nano molecular cages."J Chem Technol Biot. 2019 Jul;94(7):2248-2255 |
REACTIVE BLUE 2 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.292 ml | 6.459 ml | 12.917 ml |
| 5 mM | 0.258 ml | 1.292 ml | 2.583 ml |
| 10 mM | 0.129 ml | 0.646 ml | 1.292 ml |
| 5 mM | 0.026 ml | 0.129 ml | 0.258 ml |
Last Update：2024-01-02 23:10:35
REACTIVE BLUE 2 - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| biological activity | Procion Blue HB (Reactive Blue 2) is a purinergic antagonist. |
Last Update：2024-04-09 02:00:14
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Product Name: REACTIVE BLUE 2 Visit Supplier Webpage Request for quotationCAS: 12236-82-7
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Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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